Mansoura Veterinary Medical Journal

Thioacetamide: Definition, Exposure, Hepatic and Renal Toxicity.

Sohaila Abd El-Hameed, Department of Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.Follow
Iman Ibrahim, Department of Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.
Walaa Awadin, Department of Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.
Ahmed El-Shaieb., Dean of Faculty of Veterinary Medicine, Egyptian Chinese University, Cairo, Egypt.

Corresponding Author

Sohaila Abd El-Hameed

Authors ORCID

0000-0002-6030-4618

Document Type

Mini Review

Subject Areas

Pathology; Pharmacology and toxicology

Keywords

Thioacetamide, Oxidative stress, Hepatotoxicity, Nephrotoxicity

Abstract

Thioacetamide (TAA) is a known industrial toxic agent that is extensively used in animal studies to induce hepatic fibrosis and cirrhosis. It is a widely recognized sulfur-containing complex used in laboratory and industrial applications, metallurgy, fungicides, pesticides, and pharmaceuticals. Its administration induces hepatic encephalopathy, metabolic acidosis, centrilobular necrosis, and hepatic cirrhosis. It is hepatotoxic, nephrotoxic, and carcinogenic. The connection between liver disease and renal damage has been identified for more than a hundred years. Most hepatotoxins can cause renal damage. Hepatotoxicity refers to liver damage caused by hepatotoxins, which can include dietary supplements, medicinal plants, drugs, and chemicals. Damage to the hepatic parenchyma is associated with hepatic fibrosis and scar formation, resulting in the impairment of liver function and cirrhosis. Hepatic cirrhosis is the final stage of liver damage and liver diseases. Nephrotoxicity is defined as the damage to the kidneys caused by drugs or toxins. TAA-induced hepatotoxicity is attributed to the metabolic activation of TAA by cytochrome P450 and intermediates of TAA-induced cellular oxidative stress.

How to Cite This Article

El-Hameed, Sohaila Abd; Ibrahim, Iman; Awadin, Walaa; and El-Shaieb., Ahmed (2023) "Thioacetamide: Definition, Exposure, Hepatic and Renal Toxicity.," Mansoura Veterinary Medical Journal: Vol. 24: Iss. 4, Article 3.
DOI: https://doi.org/10.35943/2682-2512.1217