Mansoura Veterinary Medical Journal

Assessment of Possible Antiviral and immune stimulating Effects of Aloe Vera Water Extract (AVWE) on Very virulent Infectious Bursal Disease Virus Infection.

Sara M AymanFollow

Corresponding Author

Sara M Ayman

Document Type

Review Article

Subject Areas

Pharmacology and toxicology

Keywords

Aloe Vera, Antiviral, histopathology, Immune stimulant, vvIBDV.

Abstract

Objective: Evaluation of the antiviral and immunoe stimulatorying effects of Aloe vVera

Design: Experimental study.

Samples: A reference vvIBDV strain (IBDV/Dakahlia, Egypt/2016) was used as thea challenge strain.

Procedures: A 10% (AVWE) was prepared then its antiviral effect against vvIBDV was tested in embryonated chicken eggs (ECEs)., Five groups were created (Ge1-Ge5); Ge1 was a negative control, Ge2 was a positive control, and Ge3, Ge4, and Ge5 were prophylactic, antiviral, and treatment groups, respectively. While the immuno stimulatorying effects of 10% AVWE were tested in chicks, five groups were created (Gc1-Gc5); Gc1, was a negative control, Gc2 was a positive control;, and Gc3, Gc4, and Gc5, were; the protected, protected-treated, and treated groups, respectively.

Results:

In ECEs, Ge2, Ge3, and Ge5 embryos showed typical vvIBDV lesions with a high vvIBDV load in real- time RT-PCR (RRT-PCR). However, Ge1 and Ge4 embryos were normal and showed gave negative results oin RRT-PCR. In challenged birds, Gc1 did not show developed any clinical signs or PM changes. Gc2 and Gc5 showed the typical signs of vvIBDV infection signs. Gc3 and Gc4 showed developed mild symptoms signs. There was a statistically significantly lower body weight in the Gc2 group than in vs. the all other groups. Gc4 had gave the highest total leukcocyteic and lymphocyteic counts. Gc4 also showedrecorded the highest antibody titer against vvIBDV with mild histopathological lesions.

Conclusion and clinical relevance:

AVWE (10%) has a potent antiviral effect against vvIBDV, with no prophylactic or treatment effects in ECEs. In contrast On the other, hand the use of 10% AVWE before and after vvIBDV challenge in chicks showed gave a promising protective effect.

How to Cite This Article

Ayman, Sara M (2023) "Assessment of Possible Antiviral and immune stimulating Effects of Aloe Vera Water Extract (AVWE) on Very virulent Infectious Bursal Disease Virus Infection.," Mansoura Veterinary Medical Journal: Vol. 24: Iss. 4, Article 17.
DOI: https://doi.org/10.35943/2682-2512.1219