Mansoura Veterinary Medical Journal

PATHOLOGICAL, ULTRASTRUCTURAL AND HAEMATOLOGICAL STUDIES ON THE SIMULTANEOUS EFFECT OF DIETARY SUPPLEMENTATION WITH LAURIC AND BENZOIC ACIDS ON NILE TILAPIA

Abdelaziz M. Rabea, Pathology Department, Faculty of Veterinary Medicine, Mansoura University, Egypt.Follow
Iman Ibrahim, Pathology Department, Faculty of Veterinary Medicine, Mansoura University, Egypt.
Hebatallah A. Mahgoub, Pathology Department, Faculty of Veterinary Medicine, Mansoura University, Egypt.
Ahmed El- Shaieb, Pathology Department, Faculty of Veterinary Medicine, Mansoura University, Egypt.

Corresponding Author

Abdelaziz.rabea@mans.edu.eg

Document Type

Original Article

Subject Areas

Pathology

Keywords

Acidifiers, Pathology, Ultrastructure, Hematology, Nile tilapia.

Abstract

Objective: To evaluate the simultaneous effect of dietary acidifier lauric and benzoic acids on immunohematological parameters and histopathological changes in O. niloticus.

Design: Randomized controlled study.

Animal Models: The experiment was performed on 120 juvenile Nile tilapia weighing (50 ± 6.14 g).

Procedures: Fish were divided into four experimental groups (30 fish/group): Control group received normal diet; Benzoic Acid group was supplemented with benzoic acid 1 g/kg diet); Lauric Acid group was supplemented with lauric acid (1 g/kg diet); combination group was supplemented with benzoic acid (1 g/kg diet) and lauric acid (1 g/kg diet). Supplements were applied for 30 consecutive days.

Results: Our study revealed moderate histopathological changes in the liver, kidney, and intestine of fish in the benzoic acid group compared to the control group. However, no histopathological changes were observed in the lauric acid and combination groups. A significant increase was recorded in hemoglobin and total leukocytes in the lauric acid and combination groups compared to the control group.

Conclusion: Our data suggest that a single acidifier can cause mild pathological lesions in fish tissues. Meanwhile, the combined supplementation of two organic acids had a safer effect on histopathology and hematology.

How to Cite This Article

Rabea, Abdelaziz M.; Ibrahim, Iman; Mahgoub, Hebatallah A.; and El- Shaieb, Ahmed (2023) "PATHOLOGICAL, ULTRASTRUCTURAL AND HAEMATOLOGICAL STUDIES ON THE SIMULTANEOUS EFFECT OF DIETARY SUPPLEMENTATION WITH LAURIC AND BENZOIC ACIDS ON NILE TILAPIA," Mansoura Veterinary Medical Journal: Vol. 24: Iss. 3, Article 9.
DOI: https://doi.org/10.35943/2682-2512.1009