Mansoura Veterinary Medical Journal

Potential Effects of Vitamin D and Resveratrol on Hematological and Renal Indicators Associated with Metabolic Syndrome in Rats

Doha Reda, Clinical Pathology Department, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt
Gehad E. Elshopakey, Clinical Pathology Department, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt
Engy F. Risha, Clinical Pathology Department, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt
Fatma M. Abdelhamid, Clinical Pathology Department, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, EgyptFollow

Document Type

Original Article

Keywords

Metabolic syndrome, Vitamin D, Resveratrol, Hematological parameters, Renal function.

Abstract

Objective: Explore the effects of vitamin D (VD) and resveratrol (RSV) administration on hematological parameters and renal function biomarkers in rats with induced metabolic syndrome (MetS).

Design: Randomized controlled experimental study.

Animals: Forty-eight male albino rats.

Procedures: rats were randomly divided into six equal groups. Control; MetS; VD; MetS+ VD; RES and MetS +RSV. VD (1000 IU/kg; intramuscularly /three days/week), and RES were administered (30 mg/kg BW/orally/day) for 10 weeks. After that, hematological parameters, including red blood cell (RBCs) count, hemoglobin (Hb) concentration, packed cell volume (PCV), red blood cell indices, total leukocytic count (TLC), and differential leukocyte count were measured. Furthermore, the degree of renal damage was assessed by measuring serum levels of urea, creatinine, and uric acid.

Results: Rats with MetS showed insignificant changes in erythrogram results. However, they had significantly elevated TLC and neutrophilic counts, and decreased total lymphocytic count. Furthermore, they had elevated levels of urea, creatinine, and uric acid. However, VD and RES ameliorated these alterations with a more ameliorating effect upon VD treatment.

Conclusion and clinical relevance: Vitamin D and resveratrol have beneficial effects on hematological parameters and renal function in male rats with induced MetS, but VD has a more beneficial effect.

How to Cite This Article

Reda, Doha; Elshopakey, Gehad E.; Risha, Engy F.; and Abdelhamid, Fatma M. (2023) "Potential Effects of Vitamin D and Resveratrol on Hematological and Renal Indicators Associated with Metabolic Syndrome in Rats," Mansoura Veterinary Medical Journal: Vol. 24: Iss. 3, Article 3.
DOI: https://doi.org/10.35943/2682-2512.1000