Mansoura Veterinary Medical Journal

The Effect of Nitroglycerin in Testicular Histopathology, Reproductive Hormones and Testicular Oxidative Stress in Adolescent Rats

Volkan KOŞAL, Department of Artificial Insemination, Faculty of Veterinary Medicine, Van Yuzuncu Yil University, TR-65080, Van, TURKEYFollow
Çağlar OKULMUŞ, Department of Biochemistry, Izmir/Bornova Veterinary Control Institute, TR-35030 Izmir, TURKEY
Yılmaz KOÇAK, Physical Therapy and Rehabilitation, Faculty of Health Sciences, Van Yuzuncu Yil University, TR-65080, Van, Turkey
Ömer Faruk KELEŞ, Department of Pathology, Faculty of Veterinary Medicine, Van Yuzuncu Yil University, TR-65080, Van, TURKEY
Nesrin CEYLAN, Department of Pediatric Neurology University of Health Sciences, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, TR-06080, Ankara, Turkey
Yıldıray BAŞBUĞAN, Department of Internal Medicine, Faculty of Veterinary Medicine, Van Yuzuncu Yıl University, TR-65080, Van, TURKEY

Corresponding Author

Volkan KOŞAL

Authors ORCID

https://orcid.org/0000-0001-5268-5046

Document Type

Original Article

Subject Areas

Theriogenology

Keywords

Adolescent, Male, Nitroglycerin, Rat, Testis

Abstract

Background: Nitroglycerin (NTG) exerts a vasodilation effect by acting on vascular smooth muscles. The exact impact of vasodilation on the testes is not fully understood. Objectives: This study aimed to investigate the effects of NTG on the testes before the onset of spermatogenesis and reproductive activity in adolescent rats. Methods: An Average of 45 days male Albino Wistar rats were used. Two groups were formed: an adolescent control group and an adolescent NTG group (10 mg/kg, 5 d). Results: At the end of the study, testicular oxidative stress (malondialdehyde /MDA, catalase/ CAT, advanced oxidation protein products /AOPP, and nitric oxide/ NO), reproductive hormones (follicle stimulating hormone/ FSH, luteinizing hormone/ LH, Testosterone), and testicular histopathology were examined. In comparison with the control group, the testicular tissue MDA and NO levels in the NTG group were significantly increased (p

How to Cite This Article

KOŞAL, Volkan; OKULMUŞ, Çağlar; KOÇAK, Yılmaz; KELEŞ, Ömer Faruk; CEYLAN, Nesrin; and BAŞBUĞAN, Yıldıray (2023) "The Effect of Nitroglycerin in Testicular Histopathology, Reproductive Hormones and Testicular Oxidative Stress in Adolescent Rats," Mansoura Veterinary Medical Journal: Vol. 24: Iss. 3, Article 12.
DOI: https://doi.org/10.35943/2682-2512.1228