Mansoura Veterinary Medical Journal

Adverse effect of Nitroxynil and Albendazole on rabbits

Eman Elalfy, Animal Health Research Institute, Mansoura
Azza Hassan, Animal Health Research Institute, Mansoura
Magdy Amer, Pharmacology Department, Faculty of Veterinary Medicine, Mansoura University, 35516, EgyptFollow

Corresponding Author

Amer, Magdy

Document Type

Original Article

Subject Areas

Pharmacology and toxicology

Keywords

Nitroxynil, albendazole, GSH, MDA, CAT, Rabbit

Abstract

Objective:The present study aims to investigate the possible adverse effects of the subcutaneous injection of nitroxynil and oral administration of albendazole in rabbits. Design:Randomized controlled experimental study. Animals: 18 New Zealand rabbits of 1.50 ± 0.5 kg body weight, were allocated randomly into three groups (n=6). Procedures: Group A served as control, the group B was treated with albendazole (20 mg /kg B. wt.) orally and the group C was treated with nitroxynil (10mg /kg B. wt.) subcutaneously. Blood samples were collected at 1st, 7th and 14th days post drugs administration for hematological and biochemical determination. In addition, histopathological examination of liver, kidney and intestine specimens were performed. Results:The obtained results evoked a significant decrease in RBCs, PCV, Hb, WBCs, lymphocytes , neutrophils, GSH and catalase values in group B and C compared with that group A. On the other hand, group B and C elevated serum ALT, AST, urea, creatinine, and MDA significantly (P ≤0.05) compared with group A

How to Cite This Article

Elalfy, Eman; Hassan, Azza; and Amer, Magdy (2021) "Adverse effect of Nitroxynil and Albendazole on rabbits," Mansoura Veterinary Medical Journal: Vol. 22: Iss. 4, Article 2.
DOI: https://doi.org/10.21608/mvmj.2021.215026