Mansoura Veterinary Medical Journal

Evaluation of Multimodal Anesthetic Drugs Combination in Goats undergoing laparo-ovariectomy

Elbialy Elmorsy, Veterinarian, Veterinary Sector, Dakahlia Governorate, Egypt
Khalid S. Abouelnasr, Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, 35516 Mansoura, Egypt.
Esam Mosbah, Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, 35516 Mansoura, Egypt.
Adel E. Zaghloul, Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, 35516 Mansoura, Egypt.

Document Type

Original Article

Subject Areas

Surgery

Keywords

Lidocaine, piroxicam, propofol, butorphanol, goats, Laparo-ovariectomy

Abstract

Objective: To evaluate the effect of multimodal analgesic drugs for alleviation of pain accompanying laparo-ovariectomy in goat. Design: Randomized controlled experimental study. Animals: Sixteen goats ageing 8-18 months and weighing 20 kg on average. Procedures: The proposed site of laparotomy in all animals was infiltrated with lidocaine hydrochloride 1% 15 minutes before surgery started. The goats were allocated into four groups of four animals each; first group (L): animals received Lidocaine infltration , second group (PL): animals received Piroxicam at a dose rate of 5 mg/kg IM, third group (PPL): animals received Piroxicam and Propofol at a dose rate of (5 mg/kg and 6 mg/kg, respectively), and finally fourth group (PPBL): animals received Butorphanol at a dose rate of 0.1 mg/kg in addition to Piroxicam- Propofol . Heart rate (HR), respiratory rate (RR), rectal temperature (RT), serum concentrations of lactate, creatinine, blood urea nitrogen (BUN), interleukin-6 (IL-6), Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) were determined at baseline (15 minutes prior to surgery), directly after administration of the anesthetic agent, during surgery, and post-surgery at 30 minutes, 60 minutes, 120 minutes for 1-3 days postoperatively. Additionally, the analgesia score was monitored. Results: Heart rate, respiratory rate, Serum levels of IL 6, BUN and ALT decreased significantly in PPBL group compared to the other groups (P≤0.05). In addition, analgesia scores were significantly higher in PPBL group than the other groups (P≤0.05). Conclusion and clinical relevance: It could be concluded that the use of Propofol and Butorphanol in the analgesic protocol during laparo-ovariectomy in goats can alleviate stress and pain response and could therefore potentiate the effects of local analgesics.

How to Cite This Article

Elmorsy, Elbialy; Abouelnasr, Khalid S.; Mosbah, Esam; and Zaghloul, Adel E. (2019) "Evaluation of Multimodal Anesthetic Drugs Combination in Goats undergoing laparo-ovariectomy," Mansoura Veterinary Medical Journal: Vol. 20: Iss. 4, Article 1.
DOI: https://doi.org/10.21608/mvmj.2019.20.401