Mansoura Veterinary Medical Journal

Effects of Rosemary and husk on hemogram and some biochemical parameters during treatment of ulcerative colitis in rats

Magdy Amer, Department of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt
Rasha Saleh, Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt
Mayada Rashad

Document Type

Original Article

Subject Areas

Pharmacology and toxicology

Keywords

rosemary, ulcerative colitis, Rats, hematology

Abstract

Objective: The effects of rosemary (10 mg/kg B.W) and husk (5 mg/kg B.W) on hemogram, GSH , CAT , NO, IL-1β and IL-10 of rats (40 albino rats) were investigated Design:Experimental study Animals: 40 albino rats Procedures: The 1st group was served as negative control, while the remaening groups (2nd, 3rd and 4th) were given acetic acid (4%) to induce ulcerative colitis (UC). Then the 2nd group was used as positive control, the 3rd group was orally given rosemary daily for 7 days, while the 4th group was orally administerated husk daily for 7 days. Blood and serum samples were collected from all groups at one week post dosing Results: The obtained results revealed that, both the tested plants induced a significant increase in RBCs, Hb, PCV% and lymphocyte counts and a significant decrease in WBC, neutrophil, monocyte and blood platelets of treated rats compared with the positive control group. Conclusion and clinical relevance: In addition rosemary and husk evoked a significant increase in GSH, CAT and IL-10 and a significant decrease in NO and IL-1β in serum of treated rats in comparions with the positive control group.

How to Cite This Article

Amer, Magdy; Saleh, Rasha; and Rashad, Mayada (2019) "Effects of Rosemary and husk on hemogram and some biochemical parameters during treatment of ulcerative colitis in rats," Mansoura Veterinary Medical Journal: Vol. 20: Iss. 1, Article 4.
DOI: https://doi.org/10.21608/mvmj.2019.01.105