Mansoura Veterinary Medical Journal

Antiurolithiatic effect of Cymbopogon Proximus, Alhagi Maurorum, on Sulfadimidine induced urolithiasis in male New Zealand rabbits

Sameh El-Nabtity, Departments of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Egypt
Sohair Abdllatief
Al-Sayed Al-Attar
Selwan Taha

Corresponding Author

El-Nabtity, Sameh

Document Type

Original Article

Subject Areas

Pharmacology and toxicology

Keywords

sulfadimidine, Cymbopogon proximus, Alhagi maurorum, Crystalluria, Rabbit

Abstract

present study aimed to investigate the prophylactic effect of Cymbopogon proximus and Alhagi maurorum on Sulfadimidine induced urolithiasis in rabbits . Thirty New Zealand male rabbits were allocated into six equal groups( each of five): Group(1) was used as a negative control. Group(2) were administered sulfadimidine (200mg/kg) by intramuscular injection.Groups(3) and (4) were administered sulfadimidine(200mg/kg) by intramuscular injection and 330mg/kg of Cymbopogon proximus alcoholic and aqueous extracts respectively orally.Groups(5) and (6) were administered sulfadimidine(200mg/kg) by intramuscular injection and 400mg/kg of Alhagi maurorum alcoholic and aqueous extracts respectively orally. The period of experiment was 10 days . Blood and urine samples were collected from rabbits on the 10th day. The results recorded a significant decrease in serum creatinine, urea, uric acid and crystalluria in Cymbopogon proximus and Alhagi maurorum groups compared to sulfadimidine treated group.We conclude that Cymbopogon proximus and Alhagi maurorum have a nephroprotective and antiurolithiatic effects against sulfadimidine induced crystalluria.

How to Cite This Article

El-Nabtity, Sameh; Abdllatief, Sohair; Al-Attar, Al-Sayed; and Taha, Selwan (2019) "Antiurolithiatic effect of Cymbopogon Proximus, Alhagi Maurorum, on Sulfadimidine induced urolithiasis in male New Zealand rabbits," Mansoura Veterinary Medical Journal: Vol. 20: Iss. 1, Article 11.
DOI: https://doi.org/10.21608/mvmj.2019.01.107